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A comparison of the concentrations of JNJ-Q2 at which non-clinical and clinical cardiovascular effects are observed
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A comparison of the concentrations of JNJ-Q2 at which non-clinical and clinical cardiovascular effects are observed
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A comparison of the concentrations of JNJ-Q2 at which non-clinical and clinical cardiovascular effects are observed
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Genes Selected for Molecular Analysis
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Genes Selected for Molecular Analysis
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Genes Selected for Molecular Analysis
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Image Search Results


A comparison of the concentrations of JNJ-Q2 at which non-clinical and clinical cardiovascular effects are observed

Journal: British Journal of Pharmacology

Article Title: Role of mixed ion channel effects in the cardiovascular safety assessment of the novel anti-MRSA fluoroquinolone JNJ-Q2

doi: 10.1111/j.1476-5381.2012.01874.x

Figure Lengend Snippet: A comparison of the concentrations of JNJ-Q2 at which non-clinical and clinical cardiovascular effects are observed

Article Snippet: Additionally, JNJ-Q2 showed 25% binding to L-type calcium channels at 10 μM in the CEREP versus 29.2% hERG inhibition and 29.8% L-type calcium channel inhibition at 100 μM in the Patch Express assay.

Techniques: Comparison, Inhibition, Concentration Assay

Genes Selected for Molecular Analysis

Journal:

Article Title: Statin Therapy and the Expression of Genes that Regulate Calcium Homeostasis and Membrane Repair in Skeletal Muscle

doi: 10.2353/ajpath.2010.091140

Figure Lengend Snippet: Genes Selected for Molecular Analysis

Article Snippet: L-type Ca-channel alpha1 S subunit = dihydropyridine receptor , CACNA1S Hs00163885_m1 , 0.001 , 0.457.

Techniques: Binding Assay